Human ZNF346 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ZNF346
Locus ID	23567
Kit Components	GA108405G1, ZNF346 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108405G2, ZNF346 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108405G3, ZNF346 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001308213, NM_001308214, NM_001308215, NM_001308216, NM_001308218, NM_001308219, NM_001308221, NM_001308223, NM_012279, NR_131773, NR_131774, NM_001363713
Synonyms	JAZ; Zfp346
Summary	The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

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