Human KAT6B activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	KAT6B
Locus ID	23522
Kit Components	GA108366G1, KAT6B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108366G2, KAT6B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108366G3, KAT6B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001256468, NM_001256469, NM_012330, NM_001370133, NM_001370136, NM_001370140, NM_001370141, NM_001370143, NM_001370144, NM_001370132, NM_001370134, NM_001370135, NM_001370137, NM_001370138, NM_001370139, NM_001370142
Synonyms	GTPTS; MORF; MOZ2; MYST4; qkf; querkopf; ZC2HC6B
Summary	The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

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