Human SIRT3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SIRT3
Locus ID	23410
Kit Components	GA108288G1, SIRT3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108288G2, SIRT3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108288G3, SIRT3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001017524, NM_012239, NM_001370312, NM_001370314, NM_001370316, NM_001370318, NM_001370319, NM_001370325, NR_163386, NR_163388, NR_163389, NR_163390, NR_163391, NR_163393, NR_163394, NR_163398, NR_163399, NR_163400, NR_163401, NM_001370310, NM_001370315, NM_001370317, NM_001370320, NM_001370321, NM_001370322, NM_001370323, NM_001370324, NR_163387, NR_163392, NR_163395, NR_163396, NR_163397, NR_163402
Synonyms	SIR2L3
Summary	SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]

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