Human LIMCH1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	LIMCH1
Locus ID	22998
Kit Components	GA107959G1, LIMCH1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107959G2, LIMCH1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107959G3, LIMCH1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001112717, NM_001112718, NM_001112719, NM_001112720, NM_001289122, NM_001289124, NM_001330672, NM_001330674, NM_001330784, NM_001330786, NM_001330787, NM_001330788, NM_001330789, NM_001330790, NM_001330791, NM_001330792, NM_001330793, NM_001330982, NM_001330983, NM_014988
Synonyms	LIMCH1A; LMO7B
Summary	Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration.[UniProtKB/Swiss-Prot Function]

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