Human ADAMTS6 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ADAMTS6
Locus ID	11174
Kit Components	GA107696G1, ADAMTS6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107696G2, ADAMTS6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107696G3, ADAMTS6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_014273, NM_197941, NR_135689
Synonyms	ADAM-TS6; ADAM metallopeptidase with thrombospondin type 1 motif, 6; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6; a disintegrin and metalloproteinase with thrombospondin motifs 6
Summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Expression of this gene may be regulated by the cytokine TNF-alpha. [provided by RefSeq, Mar 2016]

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