Human IRE1 (ERN2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ERN2
Locus ID	10595
Kit Components	GA107251G1, IRE1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107251G2, IRE1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107251G3, IRE1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001308220, NM_033266
Synonyms	hIRE2p; IRE1-BETA; IRE1b; IRE2p
Summary	Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.[UniProtKB/Swiss-Prot Function]

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