Human SRRM1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SRRM1
Locus ID	10250
Kit Components	GA106978G1, SRRM1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106978G2, SRRM1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106978G3, SRRM1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001303448, NM_001303449, NM_005839, NM_001366577, NM_001366589, NM_001366600, NM_001366566, NM_001366567, NM_001366569, NM_001366570, NM_001366572, NM_001366575, NM_001366576, NM_001366581, NM_001366582, NM_001366585, NM_001366587, NM_001366590, NM_001366592, NM_001366594, NM_001366595, NM_001366596, NM_001366597, NM_001366599, NR_159379, NR_159382, NR_159383, NR_159384, NR_159385, NR_159386, NR_159387, NR_159388, NR_159389, NR_159391, NM_001366565, NM_001366568, NM_001366571, NM_001366573, NM_001366578, NM_001366584, NM_001366586, NM_001366588, NM_001366591, NM_001366593, NM_001366598, NR_159378, NR_159380, NR_159390
Synonyms	160-KD; POP101; SRM160
Summary	Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.[UniProtKB/Swiss-Prot Function]

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