Human Bile Acid Receptor (NR1H4) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	NR1H4
Locus ID	9971
Kit Components	GA106749G1, Bile Acid Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106749G2, Bile Acid Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106749G3, Bile Acid Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001206977, NM_001206978, NM_001206979, NM_001206992, NM_001206993, NM_005123, NR_135146
Synonyms	BAR; FXR; HRR-1; HRR1; PFIC5; RIP14
Summary	This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]

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