Human KIAA0020 (PUM3) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PUM3
Locus ID	9933
Kit Components	GA106716G1, KIAA0020 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106716G2, KIAA0020 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106716G3, KIAA0020 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001031691, NM_014878
Synonyms	HBV X-transactivated gene 5 protein; HLA-HA8; KIAA0020 protein; MGC8749; minor histocompatibility antigen HA-8; PEN; penguin homolog; protein 5 transactivated by hepatitis B virus X antigen (HBxAg); PUF6; XTP5; XTP5, HLA-HA8, MGC8749, RP11-526D20.2
Summary	Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity).[UniProtKB/Swiss-Prot Function]

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