Human HDAC9 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	HDAC9
Locus ID	9734
Kit Components	GA106542G1, HDAC9 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106542G2, HDAC9 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106542G3, HDAC9 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001204144, NM_001204145, NM_001204146, NM_001204147, NM_001204148, NM_001321868, NM_001321869, NM_001321870, NM_001321871, NM_001321872, NM_001321873, NM_001321874, NM_001321875, NM_001321876, NM_001321877, NM_001321878, NM_001321879, NM_001321884, NM_001321885, NM_001321886, NM_001321887, NM_001321888, NM_001321889, NM_001321890, NM_001321893, NM_001321894, NM_001321895, NM_001321896, NM_001321897, NM_001321898, NM_001321899, NM_001321900, NM_001321901, NM_001321902, NM_014707, NM_058176, NM_058177, NM_178423, NM_178425, NR_135835, NM_001321891
Synonyms	HD7; HD7b; HD9; HDAC; HDAC7; HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR
Summary	Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]

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