Human CBF1 interacting corepressor (CIR1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CIR1
Locus ID	9541
Kit Components	GA106385G1, CBF1 interacting corepressor gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106385G2, CBF1 interacting corepressor gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106385G3, CBF1 interacting corepressor gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_004882, NM_199075
Synonyms	CIR
Summary	May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.[UniProtKB/Swiss-Prot Function]

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