Human PIAS2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PIAS2
Locus ID	9063
Kit Components	GA106028G1, PIAS2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106028G2, PIAS2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106028G3, PIAS2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_004671, NM_173206, NM_001324046, NM_001324047, NM_001324048, NM_001324049, NM_001324051, NM_001324052, NM_001324053, NM_001324054, NM_001324055, NM_001324057, NM_001324058, NM_001324059, NM_001324060, NM_001354033, NM_001354034, NM_001354035, NM_001354036, NM_001354037, NM_001354038, NM_001354039, NR_136684, NR_136685, NR_148699, NR_148700, NR_148701, NR_148702, NR_148703
Synonyms	ARIP3; DIP; MIZ; MIZ1; PIASX; PIASX-ALPHA; PIASX-BETA; SIZ2; ZMIZ4
Summary	This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]

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