Human Apoptosis inhibitor 5 (API5) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	API5
Locus ID	8539
Kit Components	GA105653G1, Apoptosis inhibitor 5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105653G2, Apoptosis inhibitor 5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105653G3, Apoptosis inhibitor 5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001142930, NM_001142931, NM_001243747, NM_006595, NM_021112, NR_024625
Synonyms	AAC-11; AAC11
Summary	This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

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