Human ZNF148 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ZNF148
Locus ID	7707
Kit Components	GA105266G1, ZNF148 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105266G2, ZNF148 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105266G3, ZNF148 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_021964, NM_001348424, NM_001348425, NM_001348426, NM_001348427, NM_001348428, NM_001348429, NM_001348430, NM_001348431, NM_001348432, NM_001348433, NM_001348434, NM_001348436
Synonyms	BERF-1; BFCOL1; HT-BETA; pHZ-52; ZBP-89; ZFP148
Summary	The protein encoded by this gene is a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Increased expression of this gene results in decreased patient survival rates from colorectal cancer, while mutations in this gene have been associated with global developmental delay, hypoplastic corpus callosum, and dysmorphic facies. [provided by RefSeq, Feb 2017]

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