Human Tryptophan rich protein (WRB) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GET1
Locus ID	7485
Kit Components	GA105161G1, Tryptophan rich protein gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105161G2, Tryptophan rich protein gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105161G3, Tryptophan rich protein gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001146218, NM_004627, NM_001350293, NM_001350294, NM_001350295, NM_001350296, NR_146614, NR_146615, NR_146616
Synonyms	CHD5
Summary	This gene is located in the candidate region for congenital heart disease (CHD) in Down syndrome (DS). It encodes a basic protein that functions as a receptor that promotes insertion of tail-anchored proteins in the endoplasmic reticulum membrane. This gene is located at a maternally-methylated differentially methylated region (DMR); however, its transcription may be biallelic, not imprinted. Alternative splicing results in different transcript variants. A pseudogene has been defined on chromosome 4. [provided by RefSeq, Apr 2017]

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