Human SM22 alpha (TAGLN) activation kit by CRISPRa

CAT#: GA104735

TAGLN CRISPRa kit - CRISPR gene activation of human transgelin



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
TAGLN mouse monoclonal antibody, clone OTI8C8 (formerly 8C8)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


TAGLN (Myc-DDK-tagged)-Human transgelin (TAGLN), transcript variant 2
    • 10 ug

CNY 2,400.00
CNY 3,705.00


Rabbit monoclonal anti-TAGL antibody for SISCAPA, clone OTIR1F8
    • 100 ul

CNY 4,390.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol TAGLN
Locus ID 6876
Kit Components

GA104735G1, SM22 alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA104735G2, SM22 alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA104735G3, SM22 alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001001522, NM_003186
Synonyms SM22; SMCC; TAGLN1; WS3-10
Summary This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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