Human PMS1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PMS1
Locus ID	5378
Kit Components	GA103631G1, PMS1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103631G2, PMS1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103631G3, PMS1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000534, NM_001128143, NM_001128144, NM_001289408, NM_001289409, NR_110332, NM_001321044, NM_001321045, NM_001321046, NM_001321047, NM_001321048, NM_001321049, NM_001321051
Synonyms	HNPCC3; hPMS1; MLH2; PMSL1
Summary	This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. [provided by RefSeq, Jul 2008]

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