Human PFKM activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PFKM
Locus ID	5213
Kit Components	GA103503G1, PFKM gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103503G2, PFKM gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103503G3, PFKM gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000289, NM_001166686, NM_001166687, NM_001166688, NM_001354735, NM_001354736, NM_001354737, NM_001354738, NM_001354739, NM_001354740, NM_001354741, NM_001354742, NM_001354743, NM_001354744, NM_001354745, NM_001354746, NM_001354747, NM_001354748, NR_148954, NR_148955, NR_148956, NR_148957, NR_148958, NR_148959, NM_001363619
Synonyms	ATP-PFK; GSD7; PFK-1; PFK1; PFKA; PFKX; PPP1R122
Summary	Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]

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