Human MTRR activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MTRR
Locus ID	4552
Kit Components	GA103030G1, MTRR gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103030G2, MTRR gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103030G3, MTRR gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_002454, NM_024010, NR_134480, NR_134481, NR_134482, NM_001364440, NM_001364442, NR_157168, NR_157172, NR_157175, NR_157176, NR_157177, NR_157178, NM_001364441, NR_157169, NR_157170, NR_157171, NR_157173, NR_157174
Synonyms	cblE; MSR
Summary	This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

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