Human MDM2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MDM2
Locus ID	4193
Kit Components	GA102858G1, MDM2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102858G2, MDM2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102858G3, MDM2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001145336, NM_001145337, NM_001145339, NM_001145340, NM_001278462, NM_002392, NM_006878, NM_006879, NM_006880, NM_006881, NM_006882, NM_001367990
Synonyms	hdm2; HDMX; MGC5370; MGC71221
Summary	This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]

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