Human LDL Receptor (LDLR) activation kit by CRISPRa

CAT#: GA102675

LDLR CRISPRa kit - CRISPR gene activation of human low density lipoprotein receptor



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
LDLR mouse monoclonal antibody,clone OTI7C5
    • 100 ul

CNY 1,999.00
CNY 2,700.00


LDLR (Myc-DDK-tagged)-Human low density lipoprotein receptor (LDLR), transcript variant 1
    • 10 ug

CNY 9,448.00


LDLR mouse monoclonal antibody,clone OTI7C5
    • 30 ul

CNY 800.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol LDLR
Locus ID 3949
Kit Components

GA102675G1, LDL Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102675G2, LDL Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102675G3, LDL Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_000527, NM_001195798, NM_001195799, NM_001195800, NM_001195802, NM_001195803
Synonyms FH; FHC; LDLCQ2
Summary The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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