Human Insulin (INS) activation kit by CRISPRa

CAT#: GA102433

INS CRISPRa kit - CRISPR gene activation of human insulin



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

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    • 100 ul

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Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol INS
Locus ID 3630
Kit Components

GA102433G1, Insulin gRNA vector 1 in pCas-Guide-GFP-CRISPRa, Target Sequence: CCAGCACCAGGGAAATGGTC

GA102433G2, Insulin gRNA vector 2 in pCas-Guide-GFP-CRISPRa, Target Sequence: GGGTTGAGAGGTAGGGGAGA

GA102433G3, Insulin gRNA vector 3 in pCas-Guide-GFP-CRISPRa, Target Sequence: GTCGTCAGCACCTCTTCCTC

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_000207, NM_001185097, NM_001185098, NM_001291897
Synonyms IDDM; IDDM1; IDDM2; ILPR; IRDN; MODY10
Summary This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes diabetes mellitus, maturity-onset diabetes of the young type 10 and hyperproinsulinemia. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq, May 2020]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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