Human HLA-DRB1 activation kit by CRISPRa
CAT#: GA102133
HLA-DRB1 CRISPRa kit - CRISPR gene activation of human major histocompatibility complex, class II, DR beta 1
CNY 12,255.00
货期*
4周
规格
经常一起买 (3)
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | HLA-DRB1 |
Locus ID | 3123 |
Kit Components | GA102133G1, HLA-DRB1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102133G2, HLA-DRB1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102133G3, HLA-DRB1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001243965, NM_002124, NM_001359193, NM_001359194 |
Synonyms | DRB1; DRw10; HLA-DR1B; HLA-DRB; SS1 |
Summary | HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene. [provided by RefSeq, Jul 2020] |
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