Human HLA DMB (HLA-DMB) activation kit by CRISPRa
CAT#: GA102121
HLA-DMB CRISPRa kit - CRISPR gene activation of human major histocompatibility complex, class II, DM beta
CNY 12,255.00
货期*
4周
规格
经常一起买 (2)
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | HLA-DMB |
Locus ID | 3109 |
Kit Components | GA102121G1, HLA DMB gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102121G2, HLA DMB gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102121G3, HLA DMB gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_002118 |
Synonyms | D6S221E; RING7 |
Summary | HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] |
Documents
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基因表达相关资源 |
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