Human GLP1R activation kit by CRISPRa
CAT#: GA101827
GLP1R CRISPRa kit - CRISPR gene activation of human glucagon like peptide 1 receptor
CNY 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | GLP1R |
Locus ID | 2740 |
Kit Components | GA101827G1, GLP1R gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101827G2, GLP1R gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101827G3, GLP1R gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_002062, NR_136562, NR_136563 |
Synonyms | MGC138331 |
Summary | This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN411333 | GLP1R - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |