Human Gastric Inhibitory Polypeptide Receptor (GIPR) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GIPR
Locus ID	2696
Kit Components	GA101802G1, Gastric Inhibitory Polypeptide Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101802G2, Gastric Inhibitory Polypeptide Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101802G3, Gastric Inhibitory Polypeptide Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000164, NM_001308418
Synonyms	PGQTL2
Summary	This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]

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