Human FKBP12 (FKBP1A) activation kit by CRISPRa

CAT#: GA101597

FKBP1A CRISPRa kit - CRISPR gene activation of human FKBP prolyl isomerase 1A



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
FKBP1A (FKBP12) mouse monoclonal antibody, clone OTI3B3 (formerly 3B3)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


FKBP1A (Myc-DDK-tagged)-Human FK506 binding protein 1A, 12kDa (FKBP1A), transcript variant 1
    • 10 ug

CNY 1,200.00
CNY 3,705.00


FKBP1A (FKBP12) mouse monoclonal antibody, clone OTI3B3 (formerly 3B3)
    • 30 ul

CNY 800.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol FKBP1A
Locus ID 2280
Kit Components

GA101597G1, FKBP12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA101597G2, FKBP12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA101597G3, FKBP12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_000801, NM_001199786, NM_054014
Synonyms FKBP-1A; FKBP-12; FKBP1; FKBP12; PKC12; PKCI2; PPIASE
Summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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