Human Factor XIIIa (F13A1) activation kit by CRISPRa

CAT#: GA101507

F13A1 CRISPRa kit - CRISPR gene activation of human coagulation factor XIII A chain



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
F13A1 (Factor XIIIa) mouse monoclonal antibody, clone OTI6F5 (formerly 6F5)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


F13A1 (Myc-DDK-tagged)-Human coagulation factor XIII, A1 polypeptide (F13A1)
    • 10 ug

CNY 8,040.00


F13A1 (Factor XIIIa) mouse monoclonal antibody, clone OTI8E2 (formerly 8E2)
    • 30 ul

CNY 800.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol F13A1
Locus ID 2162
Kit Components

GA101507G1, Factor XIIIa gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA101507G2, Factor XIIIa gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA101507G3, Factor XIIIa gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_000129
Synonyms F13A
Summary This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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