Human Endothelin A Receptor (EDNRA) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	EDNRA
Locus ID	1909
Kit Components	GA101330G1, Endothelin A Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101330G2, Endothelin A Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101330G3, Endothelin A Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001166055, NM_001256283, NM_001957, NR_028596, NR_045958, NM_001354797, NR_148963, NR_148964
Synonyms	ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR
Summary	This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

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