Human Deoxyguanosine kinase (DGUOK) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DGUOK
Locus ID	1716
Kit Components	GA101191G1, Deoxyguanosine kinase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101191G2, Deoxyguanosine kinase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101191G3, Deoxyguanosine kinase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001318859, NM_001318860, NM_001318861, NM_001318862, NM_001318863, NM_001929, NM_080915, NM_080916, NM_080917, NM_080918, NR_134893, NR_134894, NR_134895, NR_134896, NR_134897, NR_134898
Synonyms	deoxyguanosine kinase; deoxyguanosine kinase, mitochondrial; dGK; OTTHUMP00000160251; OTTHUMP00000160252
Summary	In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

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