Human Cytochrome P450 3A5 (CYP3A5) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CYP3A5
Locus ID	1577
Kit Components	GA101108G1, Cytochrome P450 3A5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101108G2, Cytochrome P450 3A5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101108G3, Cytochrome P450 3A5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000777, NM_001190484, NM_001291829, NM_001291830, NR_033807, NR_033808, NR_033809, NR_033810, NR_033811, NR_033812
Synonyms	CP35; CYPIIIA5; P450PCN3; PCN3
Summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

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