Human Nicotinic Acetylcholine Receptor alpha 4 (CHRNA4) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CHRNA4
Locus ID	1137
Kit Components	GA100814G1, Nicotinic Acetylcholine Receptor alpha 4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100814G2, Nicotinic Acetylcholine Receptor alpha 4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100814G3, Nicotinic Acetylcholine Receptor alpha 4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000744, NM_001256573, NR_046317
Synonyms	BFNC; EBN; EBN1; NACHR; NACHRA4; NACRA4
Summary	This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

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