XRCC1 (NM_006297) Human Mutant ORF Clone

Specifications

Product Data
Product Name	XRCC1 (NM_006297) Human Mutant ORF Clone
Mutation Description	R280H
Affected Codon#	280
Affected NT#	839
Nucleotide Mutation	XRCC1 Mutant (R280H), Myc-DDK-tagged ORF clone of Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1) as transfection-ready DNA
Effect	Inresed lun nerisk, ssoiion wih
Synonyms	RCC; SCAR26
Vector	pCMV6-Entry
Tag	Myc-DDK
ACCN	NM_006297
ORF Size	1899 bp
Sequence Data	ORF Nucleotide Sequence (showhide) >RC402803 representing NM_006297 Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGCCGGAGATCCGCCTCCGCCATGTCGTGTCCTGCAGCAGCCAGGACTCGACTCACTGTGCAGAAAATC TTCTCAAGGCAGACACTTACCGAAAATGGCGGGCAGCCAAGGCAGGCGAGAAGACCATCTCTGTGGTCCT ACAGTTGGAGAAGGAGGAGCAGATACACAGTGTGGACATTGGGAATGATGGCTCAGCTTTCGTGGAGGTG CTGGTGGGCAGTTCAGCTGGAGGCGCTGGGGAGCAAGACTATGAGGTCCTTCTGGTCACCTCATCTTTCA TGTCCCCTTCCGAGAGCCGCAGTGGCTCAAACCCCAACCGCGTTCGCATGTTTGGGCCTGACAAGCTGGT CCGGGCAGCCGCCGAGAAGCGCTGGGACCGGGTCAAAATTGTTTGCAGCCAGCCCTACAGCAAGGACTCC CCCTTTGGCTTGAGTTTTGTACGGTTTCATAGCCCCCCAGACAAAGATGAGGCAGAGGCCCCGTCCCAGA AGGTGACAGTGACCAAGCTTGGCCAGTTCCGTGTGAAGGAGGAGGATGAGAGCGCCAACTCTCTGAGGCC GGGGGCTCTCTTCTTCAGCCGGATCAACAAGACATCCCCAGTCACAGCCAGCGACCCAGCAGGACCTAGC TATGCAGCTGCTACCCTCCAGGCTTCTAGTGCTGCCTCCTCAGCCTCTCCAGTCTCCAGGGCCATAGGCA GCACCTCCAAGCCCCAGGAGTCTCCCAAAGGGAAGAGGAAGTTGGATTTGAACCAAGAAGAAAAGAAGAC CCCCAGCAAACCACCAGCCCAGCTGTCGCCATCTGTTCCCAAGAGACCTAAATTGCCAGCTCCAACTCAT ACCCCAGCCACAGCCCCAGTCCCTGCCCGAGCACAGGGGGCAGTGACAGGCAAACCCCGAGGAGAAGGCA CCGAGCCCAGACGACCCCGAGCTGGCCCAGAGGAGCTGGGGAAGATCCTTCAGGGTGTGGTAGTGGTGCT GAGTGGCTTCCAGAACCCCTTCCGCTCCGAGCTGCGAGATAAGGCCCTAGAGCTTGGGGCCAAGTATCGG CCAGACTGGACCCGGGACAGCACGCACCTCATCTGTGCCTTTGCCAACACCCCCAAGTACAGCCAGGTCC TAGGCCTGGGAGGCCGCATCGTGCGTAAGGAGTGGGTGCTGGACTGTCACCGCATGCGTCGGCGGCTGCC CTCCCAGAGGTACCTCATGGCAGGGCCAGGTTCCAGCAGTGAGGAGGATGAGGCCTCTCACAGCGGTGGC AGCGGAGATGAAGCCCCCAAGCTTCCTCAGAAGCAACCCCAGACCAAAACCAAGCCCACTCAGGCAGCTG GACCCAGCTCACCCCAGAAGCCCCCAACCCCTGAAGAGACCAAAGCAGCCTCACCAGTGCTCCAGGAAGA TATAGACATTGAGGGGGTACAGTCAGAAGGACAGGACAATGGGGCGGAAGATTCTGGGGACACAGAGGAT GAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGAGAATGGGGAAGACC CGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCC TGAGCTCCCAGATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGG AAACTCATCCGATACGTCACAGCCTTCAATGGGGAGCTCGAGGACTATATGAGTGACCGGGTTCAGTTTG TGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCCTGATGGACAACCCCTCCCTGGCATTCGT TCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTG CCGCAAGCC AGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCC TGGATTACAAGGATGACGACGA TAAGGTTTAA Protein Sequence (showhide) >RC402803 representing NM_006297 Red=Cloning site Green=Tags(s) MPEIRLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDIGNDGSAFVEV LVGSSAGGAGEQDYEVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLVRAAAEKRWDRVKIVCSQPYSKDS PFGLSFVRFHSPPDKDEAEAPSQKVTVTKLGQFRVKEEDESANSLRPGALFFSRINKTSPVTASDPAGPS YAAATLQASSAASSASPVSRAIGSTSKPQESPKGKRKLDLNQEEKKTPSKPPAQLSPSVPKRPKLPAPTH TPATAPVPARAQGAVTGKPRGEGTEPRRPRAGPEELGKILQGVVVVLSGFQNPFRSELRDKALELGAKYR PDWTRDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMRRRLPSQRYLMAGPGSSSEEDEASHSGG SGDEAPKLPQKQPQTKTKPTQAAGPSSPQKPPTPEETKAASPVLQEDIDIEGVQSEGQDNGAEDSGDTED ELRRVAEQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERR KLIRYVTAFNGELEDYMSDRVQFVITAQEWDPSFEEALMDNPSLAFVRPRWIYSCNEKQKLLPHQLYGVV PQA SGPTRTRRLEQKLISEEDLAANDILDYKDDDDKV
Restriction Sites	SgfI-MluI      Cloning Scheme for this gene
OTI Disclaimer	Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation	This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq	NP_006288
RefSeq Size	1899 bp
RefSeq ORF	1902 bp
Locus ID	7515
Domains	BRCT, XRCC1_N
Protein Families	Druggable Genome
Protein Pathways	Base excision repair
MW	69.6 kDa
Gene Summary	The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

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