p27 KIP 1 (CDKN1B) (NM_004064) Human Mutant ORF Clone

Specifications

Product Data
Product Name	p27 KIP 1 (CDKN1B) (NM_004064) Human Mutant ORF Clone
Mutation Description	I119T
Affected Codon#	119
Affected NT#	356
Nucleotide Mutation	CDKN1B Mutant (I119T), Myc-DDK-tagged ORF clone of Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B) as transfection-ready DNA
Effect	Myeloproliferative syndrome
Synonyms	CDKN4; KIP1; MEN1B; MEN4; P27KIP1
Vector	pCMV6-Entry
Tag	Myc-DDK
ACCN	NM_004064
ORF Size	594 bp
Restriction Sites	SgfI-MluI      Cloning Scheme for this gene
OTI Disclaimer	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation	This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq	NP_004055
RefSeq Size	594 bp
RefSeq ORF	597 bp
Locus ID	1027
Domains	CDI
Protein Families	Druggable Genome
Protein Pathways	Cell cycle, Chronic myeloid leukemia, ErbB signaling pathway, Pathways in cancer, Prostate cancer, Small cell lung cancer
MW	21.8 kDa
Gene Summary	This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]

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