Jagged 2 (JAG2) (NM_002226) Human Mutant ORF Clone

Specifications

Product Data
Product Name	Jagged 2 (JAG2) (NM_002226) Human Mutant ORF Clone
Mutation Description	M597I
Affected Codon#	597
Affected NT#	1791
Nucleotide Mutation	JAG2 Mutant (M597I), Myc-DDK-tagged ORF clone of Homo sapiens jagged 2 (JAG2), transcript variant 1 as transfection-ready DNA
Effect	Cleft lip ?
Synonyms	HJ2; SER2
Vector	pCMV6-Entry
Tag	Myc-DDK
ACCN	NM_002226
ORF Size	3714 bp
Sequence Data	ORF Nucleotide Sequence (showhide) >RC402616 representing NM_002226 Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGCGGGCGCAGGGCCGGGGGCGCCTTCCCCGGCGGCTGCTGCTGCTGCTGGCGCTCTGGGTGCAGGCGG CGCGGCCCATGGGCTATTTCGAGCTGCAGCTGAGCGCGCTGCGGAACGTGAACGGGGAGCTGCTGAGCGG CGCCTGCTGTGACGGCGACGGCCGGACAACGCGCGCGGGGGGCTGCGGCCACGACGAGTGCGACACGTAC GTGCGCGTGTGCCTTAAGGAGTACCAGGCCAAGGTGACGCCCACGGGGCCCTGCAGCTACGGCCACGGCG CCACGCCCGTGCTGGGCGGCAACTCCTTCTACCTGCCGCCGGCGGGCGCTGCGGGGGACCGAGCGCGGGC GCGGGCCCGGGCCGGCGGCGACCAGGACCCGGGCCTCGTCGTCATCCCCTTCCAGTTCGCCTGGCCGCGC TCCTTTACCCTCATCGTGGAGGCCTGGGACTGGGACAACGATACCACCCCGAATGAGGAGCTGCTGATCG AGCGAGTGTCGCATGCCGGCATGATCAACCCGGAGGACCGCTGGAAGAGCCTGCACTTCAGCGGCCACGT GGCGCACCTGGAGCTGCAGATCCGCGTGCGCTGCGACGAGAACTACTACAGCGCCACTTGCAACAAGTTC TGCCGGCCCCGCAACGACTTTTTCGGCCACTACACCTGCGACCAGTACGGCAACAAGGCCTGCATGGACG GCTGGATGGGCAAGGAGTGCAAGGAAGCTGTGTGTAAACAAGGGTGTAATTTGCTCCACGGGGGATGCAC CGTGCCTGGGGAGTGCAGGTGCAGCTACGGCTGGCAAGGGAGGTTCTGCGATGAGTGTGTCCCCTACCCC GGCTGCGTGCATGGCAGTTGTGTGGAGCCCTGGCAGTGCAACTGTGAGACCAACTGGGGCGGCCTGCTCT GTGACAAAGACCTGAACTACTGTGGCAGCCACCACCCCTGCACCAACGGAGGCACGTGCATCAACGCCGA GCCTGACCAGTACCGCTGCACCTGCCCTGACGGCTACTCGGGCAGGAACTGTGAGAAGGCTGAGCACGCC TGCACCTCCAACCCGTGTGCCAACGGGGGCTCTTGCCATGAGGTGCCGTCCGGCTTCGAATGCCACTGCC CATCGGGCTGGAGCGGGCCCACCTGTGCCCTTGACATCGATGAGTGTGCTTCGAACCCGTGTGCGGCCGG TGGCACCTGTGTGGACCAGGTGGACGGCTTTGAGTGCATCTGCCCCGAGCAGTGGGTGGGGGCCACCTGC CAGCTGGACGCCAATGAGTGTGAAGGGAAGCCATGCCTTAACGCTTTTTCTTGCAAAAACCTGATTGGCG GCTATTACTGTGATTGCATCCCGGGCTGGAAGGGCATCAACTGCCATATCAACGTCAACGACTGTCGCGG GCAGTGTCAGCATGGGGGCACCTGCAAGGACCTGGTGAACGGGTACCAGTGTGTGTGCCCACGGGGCTTC GGAGGCCGGCATTGCGAGCTGGAACGAGACGAGTGTGCCAGCAGCCCCTGCCACAGCGGCGGCCTCTGCG AGGACCTGGCCGACGGCTTCCACTGCCACTGCCCCCAGGGCTTCTCCGGGCCTCTCTGTGAGGTGGATGT CGACCTTTGTGAGCCAAGCCCCTGCCGGAACGGCGCTCGCTGCTATAACCTGGAGGGTGACTATTACTGC GCCTGCCCTGATGACTTTGGTGGCAAGAACTGCTCCGTGCCCCGCGAGCCGTGCCCTGGCGGGGCCTGCA GAGTGATCGATGGCTGCGGGTCAGACGCGGGGCCTGGGATACCTGGCACAGCAGCCTCCGGCGTGTGTGG CCCCCATGGACGCTGCGTCAGCCAGCCAGGGGGCAACTTTTCCTGCATCTGTGACAGTGGCTTTACTGGC ACCTACTGCCATGAGAACATTGACGACTGCCTGGGCCAGCCCTGCCGCAATGGGGGCACATGCATCGATG AGGTGGACGCCTTCCGCTGCTTCTGCCCCAGCGGCTGGGAGGGCGAGCTCTGCGACACCAATCCCAACGA CTGCCTTCCCGATCCCTGCCACAGCCGCGGCCGCTGCTACGACCTGGTCAATGACTTCTACTGTGCGTGC GACGACGGCTGGAAGGGCAAGACCTGCCACTCACGCGAGTTCCAGTGCGATGCCTACACCTGCAGCAACG GTGGCACCTGCTACGACAGCGGCGACACCTTCCGCTGCGCCTGCCCCCCCGGCTGGAAGGGCAGCACCTG CGCCGTCGCCAAGAACAGCAGCTGCCTGCCCAACCCCTGTGTGAATGGTGGCACCTGCGTGGGCAGCGGG GCCTCCTTCTCCTGCATCTGCCGGGACGGCTGGGAGGGTCGTACTTGCACTCACAATACCAACGACTGCA ACCCTCTGCCTTGCTACAATGGTGGCATCTGTGTTGACGGCGTCAACTGGTTCCGCTGCGAGTGTGCACC TGGCTTCGCGGGGCCTGACTGCCGCATCAACATCGACGAGTGCCAGTCCTCGCCCTGTGCCTACGGGGCC ACGTGTGTGGATGAGATCAACGGGTATCGCTGTAGCTGCCCACCCGGCCGAGCCGGCCCCCGGTGCCAGG AAGTGATCGGGTTCGGGAGATCCTGCTGGTCCCGGGGCACTCCGTTCCCACACGGAAGCTCCTGGGTGGA AGACTGCAACAGCTGCCGCTGCCTGGATGGCCGCCGTGACTGCAGCAAGGTGTGGTGCGGATGGAAGCCT TGTCTGCTGGCCGGCCAGCCCGAGGCCCTGAGCGCCCAGTGCCCACTGGGGCAAAGGTGCCTGGAGAAGG CCCCAGGCCAGTGTCTGCGACCACCCTGTGAGGCCTGGGGGGAGTGCGGCGCAGAAGAGCCACCGAGCAC CCCCTGCCTGCCACGCTCCGGCCACCTGGACAATAACTGTGCCCGCCTCACCTTGCATTTCAACCGTGAC CACGTGCCCCAGGGCACCACGGTGGGCGCCATTTGCTCCGGGATCCGCTCCCTGCCAGCCACAAGGGCTG TGGCACGGGACCGCCTGCTGGTGTTGCTTTGCGACCGGGCGTCCTCGGGGGCCAGTGCCGTGGAGGTGGC CGTGTCCTTCAGCCCTGCCAGGGACCTGCCTGACAGCAGCCTGATCCAGGGCGCGGCCCACGCCATCGTG GCCGCCATCACCCAGCGGGGGAACAGCTCACTGCTCCTGGCTGTCACCGAGGTCAAGGTGGAGACGGTTG TTACGGGCGGCTCTTCCACAGGTCTGCTGGTGCCTGTGCTGTGTGGTGCCTTCAGCGTGCTGTGGCTGGC GTGCGTGGTCCTGTGCGTGTGGTGGACACGCAAGCGCAGGAAAGAGCGGGAGAGGAGCCGGCTGCCGCGG GAGGAGAGCGCCAACAACCAGTGGGCCCCGCTCAACCCCATCCGCAACCCCATCGAGCGGCCGGGGGGCC ACAAGGACGTGCTCTACCAGTGCAAGAACTTCACGCCGCCGCCGCGCAGGGCGGACGAGGCGCTGCCCGG GCCGGCCGGCCACGCGGCCGTCAGGGAGGATGAGGAGGACGAGGATCTGGGCCGCGGTGAGGAGGACTCC CTGGAGGCGGAGAAGTTCCTCTCACACAAATTCACCAAAGATCCTGGCCGCTCGCCGGGGAGGCCGGCCC ACTGGGCCTCAGGCCCCAAAGTGGACAACCGCGCGGTCAGGAGCATCAATGAGGCCCGCTACGCCGGCAA GGAG AGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCC TGGATTACAAGGATGACGACGA TAAGGTTTAA Protein Sequence (showhide) >RC402616 representing NM_002226 Red=Cloning site Green=Tags(s) MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTY VRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPR SFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKF CRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYP GCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHA CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC QLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGF GGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYC ACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGIPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTG TYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCAC DDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSG ASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGA TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKP CLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRD HVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIV AAITQRGNSSLLLAVTEVKVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPR EESANNQWAPLNPIRNPIERPGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDS LEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE SGPTRTRRLEQKLISEEDLAANDILDYKDDDDKV
Restriction Sites	SgfI-MluI      Cloning Scheme for this gene
OTI Disclaimer	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation	This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq	NP_002217
RefSeq Size	3714 bp
RefSeq ORF	3717 bp
Locus ID	3714
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Notch signaling pathway
MW	136.2 kDa
Gene Summary	The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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