MET (NM_000245) Human Mutant ORF Clone

Specifications

Product Data
Product Name	MET (NM_000245) Human Mutant ORF Clone
Mutation Description	L982_D1028del
Affected Codon#	982
Affected NT#	c.2942_3082
Nucleotide Mutation	MET Mutant (L982_D1028del), Myc-DDK-tagged ORF clone of Homo sapiens met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 2 as transfection-ready DNA
Effect	deletion
Synonyms	AUTS9; c-Met; DFNB97; HGFR; RCCP2
Vector	pCMV6-Entry
Tag	Myc-DDK
ACCN	NM_000245
ORF Size	4029 bp
Restriction Sites	SgfI-MluI      Cloning Scheme for this gene
OTI Disclaimer	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation	This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq	NP_000236
RefSeq Size	6641 bp
RefSeq ORF	4173 bp
Locus ID	4233
Protein Families	Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways	Adherens junction, Axon guidance, Colorectal cancer, Cytokine-cytokine receptor interaction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, Focal adhesion, Melanoma, Pathways in cancer, Renal cell carcinoma
MW	150 kDa
Gene Summary	This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]

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