HOXB13 (NM_006361) Human Mutant ORF Clone

Specifications

Product Data
Product Name	HOXB13 (NM_006361) Human Mutant ORF Clone
Mutation Description	G84E
Affected Codon#	84
Affected NT#	c.251
Nucleotide Mutation	HOXB13 Mutant (G84E), Myc-DDK-tagged ORF clone of Homo sapiens homeobox B13 (HOXB13) as transfection-ready DNA
Effect	Missense
Synonyms	HPC9; PSGD
Vector	pCMV6-Entry
Tag	Myc-DDK
ACCN	NM_006361
ORF Size	852 bp
Restriction Sites	SgfI-MluI      Cloning Scheme for this gene
OTI Disclaimer	Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation	This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq	NP_006352
RefSeq Size	3047 bp
RefSeq ORF	855 bp
Locus ID	10481
Domains	homeobox
Protein Families	Transcription Factors
MW	30 kDa
Gene Summary	This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]

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