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Cadm1 (NM_001012201) Rat Tagged ORF Clone Lentiviral Particle
CAT＃: RR213821L3V
- LentiORF®
-
Lenti ORF particles, Cadm1 (Myc-DDK-tagged ORF) - Rat cell adhesion molecule 1 (Cadm1), 200ul, >10^7 TU/mL
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CNY 9,234.00
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Specifications
| Product Data | |
| Product Name | Cadm1 (NM_001012201) Rat Tagged ORF Clone Lentiviral Particle |
| Synonyms | Igsf4a; Necl-2; sgigsf; TSLC1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001012201 |
| ORF Size | 1428 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RR213821).
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| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001012201.1, NP_001012201.1 |
| RefSeq Size | 1801 bp |
| RefSeq ORF | 1431 bp |
| Locus ID | 363058 |
| Gene Summary | Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.[UniProtKB/Swiss-Prot Function] |
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