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Rnf138 (NM_053588) Rat Tagged ORF Clone Lentiviral Particle
CAT＃: RR210773L4V
- LentiORF®
-
Lenti ORF particles, Rnf138 (GFP-tagged ORF) - Rat ring finger protein 138 (Rnf138), 200ul, >10^7 TU/mL
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CNY 8,360.00
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规格
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Specifications
| Product Data | |
| Product Name | Rnf138 (NM_053588) Rat Tagged ORF Clone Lentiviral Particle |
| Synonyms | Rsd4; Trif |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_053588 |
| ORF Size | 627 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RR210773).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_053588.2, NP_446040.1 |
| RefSeq Size | 2753 bp |
| RefSeq ORF | 630 bp |
| Locus ID | 94196 |
| Gene Summary | E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.[UniProtKB/Swiss-Prot Function] |
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