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Set (NM_001012504) Rat Tagged ORF Clone Lentiviral Particle
CAT＃: RR203618L3V
- LentiORF®
-
Lenti ORF particles, Set (Myc-DDK-tagged ORF) - Rat SET nuclear oncogene (Set), 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | Set (NM_001012504) Rat Tagged ORF Clone Lentiviral Particle |
| Synonyms | Ab1-115 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001012504 |
| ORF Size | 867 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RR203618).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001012504.1, NP_001012522.1 |
| RefSeq Size | 1519 bp |
| RefSeq ORF | 870 bp |
| Locus ID | 307947 |
| Gene Summary | Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher (By similarity).[UniProtKB/Swiss-Prot Function] |
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