GPR124 (ADGRA2) (NM_032777) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC229431L4V
- LentiORF®
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Lenti ORF particles, ADGRA2 (mGFP-tagged) - Human G protein-coupled receptor 124 (GPR124), 200ul, >10^7 TU/mL
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CNY 24,035.00
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Specifications
Product Data | |
Product Name | GPR124 (ADGRA2) (NM_032777) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | GPR124; TEM5 |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_032777 |
ORF Size | 4014 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC229431).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_032777.7 |
RefSeq ORF | 4017 bp |
Locus ID | 25960 |
Protein Families | Druggable Genome, Transmembrane |
MW | 142.5 kDa |
Gene Summary | Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628).[UniProtKB/Swiss-Prot Function] |
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