SIRT1 (NM_001142498) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC227720L1V
- LentiORF®
-
Lenti ORF particles, SIRT1 (Myc-DDK-tagged)-Human sirtuin 1 (SIRT1), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 8,930.00
货期*
详询
规格
Cited in 4 publications. |
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经常一起买 (3)
SIRT1 mouse monoclonal antibody,clone OTI5B2
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Specifications
Product Data | |
Product Name | SIRT1 (NM_001142498) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | SIR2; SIR2alpha; SIR2L1 |
Vector | pLenti-C-Myc-DDK |
ACCN | NM_001142498 |
ORF Size | 1356 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC227720).
|
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001142498.1, NP_001135970.1 |
RefSeq ORF | 1359 bp |
Locus ID | 23411 |
Protein Families | Druggable Genome, Stem cell - Pluripotency, Transcription Factors |
MW | 50.3 kDa |
Gene Summary | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008] |
Citations (4)
The use of this cDNA Clones has been cited in the following citations: |
---|
SIRT1 contributes to neuroendocrine differentiation of prostate cancer
,null,
Oncotarget
,PubMed ID 29416748
[SIRT1]
|
SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis
,null,
Investigative Ophthalmology & Visual Science
,PubMed ID 29494741
[SIRT1]
|
A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease
,null,
Human Molecular Genetics
,PubMed ID 24436303
[SIRT1]
|
Effects of Sirt1 on DNA methylation and expression of genes affected by dietary restriction
,null,
Age
,PubMed ID 23229445
[SIRT1]
|
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