United States
Germany
Japan
United Kingdom
China
MMS19 (NM_022362) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC224035L1V
- LentiORF®
-
Lenti ORF particles, MMS19 (Myc-DDK tagged) - Human MMS19 nucleotide excision repair homolog (S. cerevisiae) (MMS19), 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 11,210.00
货期*
详询
规格
Product images
经常一起买 (2)
Specifications
| Product Data | |
| Product Name | MMS19 (NM_022362) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | CIAO4; hMMS19; MET18; MMS19L |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_022362 |
| ORF Size | 3090 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC224035).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_022362.3 |
| RefSeq Size | 3606 bp |
| RefSeq ORF | 3093 bp |
| Locus ID | 64210 |
| Protein Families | Druggable Genome, Transcription Factors |
| MW | 113.3 kDa |
| Gene Summary | Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription (PubMed:22678362, PubMed:22678361, PubMed:29225034, PubMed:23585563). As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633). Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery (PubMed:11279242).[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
Customer
Reviews
Loading...
