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MARK1 (NM_018650) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC221556L3V
- LentiORF®
-
Lenti ORF particles, MARK1 (Myc-DDK-tagged)-Human MAP/microtubule affinity-regulating kinase 1 (MARK1), 200ul, >10^7 TU/mL
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CNY 8,930.00
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规格
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Specifications
| Product Data | |
| Product Name | MARK1 (NM_018650) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | MARK; Par-1c; Par1c |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_018650 |
| ORF Size | 2385 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC221556).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_018650.3 |
| RefSeq Size | 5293 bp |
| RefSeq ORF | 2388 bp |
| Locus ID | 4139 |
| Domains | UBA, pkinase, TyrKc, KA1, S_TKc |
| Protein Families | Druggable Genome, Protein Kinase |
| MW | 88.8 kDa |
| Gene Summary | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).[UniProtKB/Swiss-Prot Function] |
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