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KRIT1 (NM_194455) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC220516L3V
- LentiORF®
-
Lenti ORF particles, KRIT1 (Myc-DDK-tagged)-Human KRIT1, ankyrin repeat containing (KRIT1), transcript variant 4, 200ul, >10^7 TU/mL
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CNY 8,930.00
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Specifications
| Product Data | |
| Product Name | KRIT1 (NM_194455) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | CAM; CCM1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_194455 |
| ORF Size | 2208 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC220516).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_194455.1, NP_919437.1 |
| RefSeq Size | 4997 bp |
| RefSeq ORF | 2211 bp |
| Locus ID | 889 |
| Protein Families | Druggable Genome |
| MW | 84.3 kDa |
| Gene Summary | This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009] |
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