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ULK3 (NM_001099436) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC220209L2V
- LentiORF®
-
Lenti ORF particles, ULK3 (mGFP-tagged) - Human unc-51-like kinase 3 (C. elegans) (ULK3), 200ul, >10^7 TU/mL
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CNY 9,975.00
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Specifications
| Product Data | |
| Product Name | ULK3 (NM_001099436) Human Tagged ORF Clone Lentiviral Particle |
| Vector | pLenti-C-mGFP |
| ACCN | NM_001099436 |
| ORF Size | 1416 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC220209).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001099436.1 |
| RefSeq Size | 2635 bp |
| RefSeq ORF | 1419 bp |
| Locus ID | 25989 |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | mTOR signaling pathway, Regulation of autophagy |
| MW | 53.3 kDa |
| Gene Summary | Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.[UniProtKB/Swiss-Prot Function] |
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