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Factor XIII (F13B) (NM_001994) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC219609L3V
- LentiORF®
-
Lenti ORF particles, F13B (Myc-DDK tagged) - Human coagulation factor XIII, B polypeptide (F13B), 200ul, >10^7 TU/mL
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CNY 11,305.00
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CNY 2,950.00
CNY 1,999.00
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Specifications
| Product Data | |
| Product Name | Factor XIII (F13B) (NM_001994) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | FXIIIB |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001994 |
| ORF Size | 1983 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC219609).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001994.1 |
| RefSeq Size | 2208 bp |
| RefSeq ORF | 1986 bp |
| Locus ID | 2165 |
| Protein Families | Druggable Genome |
| Protein Pathways | Complement and coagulation cascades |
| MW | 75.51 kDa |
| Gene Summary | This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008] |
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