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KMT2A (NM_005933) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC215327L1V
- LentiORF®
-
Lenti ORF particles, KMT2A (Myc-DDK tagged) - Human myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) (MLL), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 21,660.00
货期*
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规格
| Cited in 1 publication. |
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Specifications
| Product Data | |
| Product Name | KMT2A (NM_005933) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | ALL-1; CXXC7; HRX; HTRX1; MLL; MLL1; MLL1A; TRX1; WDSTS |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_005933 |
| ORF Size | 11907 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC215327).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_005933.2 |
| RefSeq Size | 14982 bp |
| RefSeq ORF | 11910 bp |
| Locus ID | 4297 |
| Domains | AT_hook, SET, BROMO, PHD, zf-CXXC, PostSET, FYRN, FYRC |
| Protein Families | Druggable Genome |
| MW | 431.6 kDa |
| Gene Summary | This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Molecular and cellular issues of KMT2A variants involved in Wiedemann-Steiner syndrome
,null,
European Journal of Human Genetics
,PubMed ID 29203834
[KMT2A]
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