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HIPK3 (NM_005734) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC214196L3V
- LentiORF®
-
Lenti ORF particles, HIPK3 (Myc-DDK tagged) - Human homeodomain interacting protein kinase 3 (HIPK3), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 20,425.00
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规格
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Specifications
| Product Data | |
| Product Name | HIPK3 (NM_005734) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | DYRK6; FIST3; PKY; YAK1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_005734 |
| ORF Size | 3645 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC214196).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_005734.2 |
| RefSeq Size | 3657 bp |
| RefSeq ORF | 3648 bp |
| Locus ID | 10114 |
| Domains | pkinase, TyrKc, S_TKc |
| Protein Families | Druggable Genome, Protein Kinase, Transcription Factors |
| MW | 133.6 kDa |
| Gene Summary | Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).[UniProtKB/Swiss-Prot Function] |
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