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EHD3 (NM_014600) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC214168L4V
- LentiORF®
-
Lenti ORF particles, EHD3 (mGFP-tagged) - Human EH-domain containing 3 (EHD3), 200ul, >10^7 TU/mL
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CNY 11,020.00
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Specifications
| Product Data | |
| Product Name | EHD3 (NM_014600) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | PAST3 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_014600 |
| ORF Size | 1605 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC214168).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_014600.1 |
| RefSeq Size | 3583 bp |
| RefSeq ORF | 1608 bp |
| Locus ID | 30845 |
| Domains | EH, EFh |
| Protein Pathways | Endocytosis |
| MW | 60.7 kDa |
| Gene Summary | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250).[UniProtKB/Swiss-Prot Function] |
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